Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 6/20 | 0.36 |
| ▸ | JAK1 | P23458 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21296776 | 0.87 | KMT2A (0.53) | MAPTALDH1A1POLBKDM4ELMNA | |
| SCHEMBL23610572 | 0.83 | KMT2A (0.54) | MAPTALDH1A1POLBKDM4ELMNA | |
| SCHEMBL21296779 | 0.78 | JAK2 (0.43) | MAPTALDH1A1POLBKDM4EJAK2 | |
| SCHEMBL21296800 | 0.76 | CNR1 (0.43) | ALDH1A1CYP17A1SCN4ASCN3ASCN9A | |
| SCHEMBL21296840 | 0.76 | ACP1 (0.42) | JAK2JAK3 | |
| SCHEMBL23610573 | 0.75 | SCN3A (0.44) | MAPTLMNAKMT2ACYP17A1SCN4A | |
| SCHEMBL21296771 | 0.75 | MAP2K4 (0.39) | MAPTHSP90AA1SCN4ASCN3ASCN9A | |
| SCHEMBL23610577 | 0.74 | HSD17B1 (0.47) | POLBKMT2ASCN4ASCN3ASCN9A | |
| SCHEMBL9110223 | 0.72 | CYP17A1 (0.52) | ALDH1A1CYP17A1TDP1 | |
| SCHEMBL21296839 | 0.72 | PDK1 (0.48) | POLBJAK2JAK1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165158-A1 | IL-6 INHIBITORS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2019-08-29 | — | — | WO | disclosed |