Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 5/20 | 0.32 |
| ▸ | HTR1B | P28222 | 5/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CBLB | Q13191 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994256 | 0.85 | NOTUM (0.42) | GABRG2GABRB3GABRA5GABRA3CYP1A2 | |
| SCHEMBL332300 | 0.73 | HDAC4 (0.37) | SMN1; SMN2HTT | |
| SCHEMBL30015400 | 0.71 | MGLL (0.47) | GABRG2GABRB3GABRA5GABRA3CYP1A2 | |
| SCHEMBL10053917 | 0.71 | HSP90AA1 (0.47) | GABRG2GABRB3GABRA5GABRA3CYP1A2 | |
| SCHEMBL2658313 | 0.71 | MGLL (0.47) | GABRG2GABRB3GABRA5GABRA3CYP1A2 | |
| SCHEMBL18394093 | 0.69 | GABRG2 (0.42) | GABRG2GABRB3GABRA5GABRA3CYP1A2 | |
| SCHEMBL12841492 | 0.68 | CYP1A2 (0.62) | CYP1A2CYP2C9LMNANOTUMPKM | |
| SCHEMBL20273069 | 0.68 | HDAC4 (0.47) | LMNANOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL859964 | 0.67 | FGFR1 (0.47) | GABRG2GABRB3GABRA5GABRA3LMNA | |
| SCHEMBL30341093 | 0.67 | MAPT (0.63) | GABRG2GABRB3GABRA5GABRA3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10392375-B2 | Heteroaryl compounds as IRAK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2019-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10392375-B2 | Heteroaryl compounds as IRAK inhibitors and uses thereof | IRAK2, IRAK3, IRAK1 | GABRG2 2241/4885GABRB3 1890/4885GABRA5 2556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.