Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | STK3 | Q13188 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21005922 | 0.86 | MPL (0.43) | MPLGRM2CRHR1HRH3SLC2A1 | |
| SCHEMBL21301055 | 0.84 | CRHR1 (0.41) | JAK2ROCK2PRKD3PRKCGPHKG2 | |
| SCHEMBL18724209 | 0.83 | JAK2 (0.38) | JAK2ROCK2PRKD3PRKCGPHKG2 | |
| SCHEMBL18724169 | 0.82 | MAPT (0.39) | CRHR1HRH3SLC2A1S1PR1ACHE | |
| SCHEMBL21301073 | 0.81 | MAPK1 (0.43) | GRM2CRHR1S1PR1ALDH1A1GAA | |
| SCHEMBL18724292 | 0.80 | CTSS (0.39) | MPLCRHR1SLC2A1S1PR1 | |
| SCHEMBL18724299 | 0.80 | CRHR1 (0.35) | MPLJAK2ROCK2PRKD3PRKCG | |
| SCHEMBL18724337 | 0.80 | CRHR1 (0.40) | MPLGRM2CRHR1HRH3SLC2A1 | |
| SCHEMBL18724238 | 0.79 | CRHR1 (0.43) | MPLCRHR1HRH3SLC2A1ACHE | |
| SCHEMBL17400621 | 0.79 | CRHR1 (0.43) | MPLCRHR1HRH3SLC2A1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963036-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2019-08-28 | — | — | EP | disclosed |