Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | STK3 | Q13188 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18724209 | 0.90 | JAK2 (0.38) | CRHR1ACHEJAK2ROCK2PRKD3 | |
| SCHEMBL19448221 | 0.89 | ACHE (0.44) | CRHR1ACHEJAK2ROCK2PRKD3 | |
| SCHEMBL17549236 | 0.87 | JAK2 (0.39) | CRHR1ACHEJAK2ROCK2PRKD3 | |
| SCHEMBL18724238 | 0.87 | CRHR1 (0.43) | CRHR1ACHESLC2A1HRH3 | |
| SCHEMBL17400621 | 0.87 | CRHR1 (0.43) | CRHR1ACHESLC2A1HRH3 | |
| SCHEMBL21300924 | 0.84 | MPL (0.40) | CRHR1ACHEJAK2ROCK2PRKD3 | |
| SCHEMBL21301049 | 0.82 | JAK2 (0.44) | JAK2ROCK2PRKD3PRKCGPHKG2 | |
| SCHEMBL21301017 | 0.81 | CRHR1 (0.40) | CRHR1ACHESLC2A1HRH3 | |
| SCHEMBL17400676 | 0.81 | CRHR1 (0.40) | CRHR1ACHESLC2A1HRH3 | |
| SCHEMBL21301033 | 0.80 | CRHR1 (0.42) | CRHR1ACHEHCRTR1IL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963036-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2019-08-28 | — | — | EP | disclosed |