Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | IL1B | P01584 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21301035 | 0.90 | CRHR1 (0.44) | CRHR1TRPV4MAPK1ALDH1A1CRHBP | |
| SCHEMBL21301073 | 0.84 | MAPK1 (0.43) | CRHR1MAPK1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL21301054 | 0.83 | CRHR1 (0.39) | CRHR1TRPV4MAPK1ALDH1A1CRHBP | |
| SCHEMBL18724209 | 0.81 | JAK2 (0.38) | CRHR1TRPV4ACHEKMT2AIL1B | |
| SCHEMBL21301055 | 0.80 | CRHR1 (0.41) | CRHR1HCRTR1ACHEIL1B | |
| SCHEMBL18724210 | 0.80 | MAPK1 (0.42) | CRHR1MAPK1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL17400676 | 0.79 | CRHR1 (0.40) | CRHR1TRPV4ALDH1A1ACHEKDM4E | |
| SCHEMBL18724088 | 0.79 | CRHR1 (0.40) | CRHR1TRPV4MAPK1ALDH1A1ENPP2 | |
| SCHEMBL21301017 | 0.79 | CRHR1 (0.40) | CRHR1TRPV4ALDH1A1ACHEKDM4E | |
| SCHEMBL21301038 | 0.79 | CRHR1 (0.42) | CRHR1MAPK1KMT2AKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963036-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2019-08-28 | — | — | EP | disclosed |