Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MPL | P40238 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18724210 | 0.84 | MAPK1 (0.42) | S1PR1CRHR1MPLSMN1; SMN2ALDH1A1 | |
| SCHEMBL21005887 | 0.82 | CRHR1 (0.38) | PDE3BPDE3AS1PR1CRHR1MPL | |
| SCHEMBL21005959 | 0.80 | MEN1 (0.47) | CRHR1MEN1ALDH1A1KMT2A | |
| SCHEMBL18724252 | 0.80 | MEN1 (0.47) | CRHR1MEN1ALDH1A1KMT2A | |
| SCHEMBL17400632 | 0.80 | MPL (0.49) | CYP2C9MPL | |
| SCHEMBL21301026 | 0.80 | CRHR1 (0.40) | S1PR1CRHR1MPLSMN1; SMN2ALDH1A1 | |
| SCHEMBL21005922 | 0.78 | MPL (0.43) | CRHR1MPLARMAPT | |
| SCHEMBL18724299 | 0.77 | CRHR1 (0.35) | CRHR1MPLJAK2MEN1KMT2A | |
| SCHEMBL18724337 | 0.77 | CRHR1 (0.40) | CRHR1MPL | |
| SCHEMBL21301073 | 0.77 | MAPK1 (0.43) | S1PR1CRHR1CYP2C9SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963036-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2019-08-28 | — | — | EP | disclosed |