Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 4/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | MPL | P40238 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21005887 | 0.91 | CRHR1 (0.38) | CRHR1CTSSMPLCTSKS1PR1 | |
| SCHEMBL18724169 | 0.90 | MAPT (0.39) | CRHR1CRHBPCRHR2SMN1; SMN2MAPT | |
| SCHEMBL21301026 | 0.90 | CRHR1 (0.40) | MAPK1CRHR1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL21301073 | 0.89 | MAPK1 (0.43) | MAPK1CRHR1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL21301076 | 0.88 | MAPT (0.43) | CRHR1ALDH1A1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL21300927 | 0.87 | MAPK1 (0.44) | MAPK1CRHR1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL21301082 | 0.86 | HTR2A (0.35) | CRHR1HTR2AKMOCTSSACHE | |
| SCHEMBL21301024 | 0.85 | MAPK1 (0.46) | MAPK1CRHR1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL21301159 | 0.85 | CRHR1 (0.50) | CRHR1ALDH1A1HTR2AKMOACHE | |
| SCHEMBL21301163 | 0.84 | NOTUM (0.40) | CRHR1ALDH1A1SMN1; SMN2MAPTMPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963036-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2019-08-28 | — | — | EP | disclosed |
| EP-3153511-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2017-04-12 | — | — | EP | disclosed |