Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15066070 | 0.71 | ALK (0.42) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL21301415 | 0.69 | KDM4E (0.32) | KDM4ENPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL22860335 | 0.68 | KDM4E (0.59) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL15086289 | 0.68 | HTR6 (0.37) | ADRA2AADRA2BADRA2CHRH4HTR6 | |
| SCHEMBL23010436 | 0.63 | KDM4E (0.51) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL23010432 | 0.61 | KDM4E (0.59) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL15066627 | 0.61 | ALK (0.42) | HTR3AHTR6HTR3EHTR3BHTR3D | |
| SCHEMBL31730808 | 0.60 | KDM4E (0.49) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL23010434 | 0.60 | HTR3A (0.54) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL5776260 | 0.60 | MAOB (0.56) | KDM4ENPC1RAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797592-B1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS INC (US) | 2019-08-28 | — | — | EP | disclosed |