Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 5/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16690711 | 0.92 | TRPM8 (0.41) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL8256880 | 0.90 | MEN1 (0.46) | TRPM8OPRK1MEN1KMT2ABACE1 | |
| SCHEMBL27691292 | 0.89 | TRPM8 (0.41) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL27691293 | 0.89 | TRPM8 (0.41) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL1491418 | 0.86 | ALDH1A1 (0.43) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL1491415 | 0.86 | ALDH1A1 (0.43) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL14878978 | 0.84 | MEN1 (0.40) | TRPM8OPRK1MEN1KMT2ABACE1 | |
| SCHEMBL1491639 | 0.84 | CACNA1B (0.39) | TRPM8OPRK1BACE1 | |
| SCHEMBL1491637 | 0.84 | CACNA1B (0.39) | TRPM8OPRK1BACE1 | |
| SCHEMBL21301649 | 0.84 | CYP2D6 (0.47) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3530290-A1 | ALPHA AMINOACID ESTER-DRUG CONJUGATES HYDROLYSABLE BY CARBOXYLESTERASE | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-08-28 | — | — | EP | disclosed |