Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22725499 | 0.84 | OPRM1 (0.49) | PDE4BOPRM1OGFRL1OPRD1KDM4E | |
| SCHEMBL21311022 | 0.81 | OPRM1 (0.47) | PDE4BOPRM1OGFRL1OPRD1KDM4E | |
| SCHEMBL25207474 | 0.77 | PDE4B (0.52) | PDE4BKDM4EMAPTTHRBNAMPT | |
| SCHEMBL30778326 | 0.76 | NAMPT (0.54) | PDE4BKDM4EMAPTTHRBNAMPT | |
| SCHEMBL15157112 | 0.76 | NAMPT (0.54) | PDE4BKDM4EMAPTTHRBNAMPT | |
| SCHEMBL31728977 | 0.76 | NAMPT (0.49) | PDE4BKDM4EMAPTTHRBNAMPT | |
| SCHEMBL25539754 | 0.76 | PDE4B (0.53) | PDE4BKDM4EMAPTTHRBNAMPT | |
| SCHEMBL14635623 | 0.75 | NAMPT (0.58) | PDE4BKDM4EMAPTTHRBNAMPT | |
| SCHEMBL21310796 | 0.74 | RORC (0.43) | PDE4BOPRM1OGFRL1OPRD1KDM4E | |
| SCHEMBL30412310 | 0.74 | DPP4 (0.51) | PDE4BKDM4EMAPTTHRBNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019162323-A1 | NEW BENZIMIDAZOLE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-08-29 | — | — | WO | disclosed |