Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.55 |
| ▸ | HRH2 | P25021 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21313262 | 0.88 | TLR8 (0.49) | ADORA2AHRH3ADORA1DHFRTLR8 | |
| SCHEMBL21313145 | 0.88 | DHFR (0.49) | ADORA2AHRH3DHFRTLR8 | |
| SCHEMBL21313221 | 0.86 | ADORA2A (0.51) | ADORA2AHRH3ADORA1ADORA3DHFR | |
| SCHEMBL12496097 | 0.85 | ADORA2A (0.62) | ADORA2AHRH2HRH3ADORA1KMT2A | |
| SCHEMBL12495753 | 0.85 | HRH3 (0.63) | ADORA2AHRH2HRH3ADORA1KMT2A | |
| SCHEMBL21313261 | 0.85 | MAPK11 (0.44) | ADORA2AHRH3ADORA1DHFRTLR8 | |
| SCHEMBL21313141 | 0.83 | ADORA2A (0.56) | ADORA2AADORA1KMT2ADPP4 | |
| SCHEMBL12495576 | 0.80 | ADORA2A (0.53) | ADORA2AHRH3ADORA1HRH4DHFR | |
| SCHEMBL21313263 | 0.80 | KDM4E (0.44) | ADORA2AHRH3ADORA1DHFRTLR8 | |
| SCHEMBL16223072 | 0.80 | ADORA2A (0.42) | ADORA2AHRH3ADORA1DHFRTLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3195867-B1 | PYRIMIDINE COMPOUNDS INHIBITING THE FORMATION OF NITRIC OXIDE AND PROSTAGLANDIN E2, METHOD OF PRODUCTION THEREOF AND USE THEREOF | USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR V V I (CZ) | 2019-09-04 | — | — | EP | claimed |