Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21313262 | 0.91 | TLR8 (0.49) | ADORA2AADORA1DHFRTLR8HRH3 | |
| SCHEMBL21313145 | 0.91 | DHFR (0.49) | ADORA2ADHFRTLR8KDM4EHRH3 | |
| SCHEMBL21313263 | 0.87 | KDM4E (0.44) | ADORA2AADORA1DHFRTLR8KDM4E | |
| SCHEMBL21313221 | 0.87 | ADORA2A (0.51) | MAPK11MAPK14ADORA2AADORA1DHFR | |
| SCHEMBL16223072 | 0.85 | ADORA2A (0.42) | MAPK11MAPK14ADORA2AADORA1DHFR | |
| SCHEMBL21313166 | 0.85 | ADORA2A (0.55) | ADORA2AADORA1DHFRTLR8HRH3 | |
| SCHEMBL21313194 | 0.84 | TLR8 (0.54) | MAPK11MAPK14ADORA2AADORA1DHFR | |
| SCHEMBL21313140 | 0.84 | TLR8 (0.46) | ADORA2AADORA1DHFRTLR8NPC1 | |
| SCHEMBL21313163 | 0.83 | TGFBR1 (0.49) | ADORA2ADHFRTLR8KDM4ENPC1 | |
| SCHEMBL21313203 | 0.82 | ADORA2A (0.48) | ADORA2AADORA1DHFRTLR8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3195867-B1 | PYRIMIDINE COMPOUNDS INHIBITING THE FORMATION OF NITRIC OXIDE AND PROSTAGLANDIN E2, METHOD OF PRODUCTION THEREOF AND USE THEREOF | USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR V V I (CZ) | 2019-09-04 | — | — | EP | claimed |