Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21323369 | 0.88 | ATXN2 (0.39) | ACHEATXN2GPR183HCRTR1HCRTR2 | |
| SCHEMBL16962750 | 0.88 | ATXN2 (0.39) | ACHEATXN2GPR183HCRTR1HCRTR2 | |
| SCHEMBL16962635 | 0.83 | ENPP2 (0.44) | ATXN2HTR2AGPR183HCRTR1HCRTR2 | |
| SCHEMBL16962636 | 0.83 | ENPP2 (0.44) | ATXN2HTR2AGPR183HCRTR1HCRTR2 | |
| SCHEMBL16962634 | 0.83 | ENPP2 (0.44) | ATXN2HTR2AGPR183HCRTR1HCRTR2 | |
| SCHEMBL21322927 | 0.79 | GPR183 (0.40) | ATXN2GPR183HCRTR1HCRTR2 | |
| SCHEMBL16963518 | 0.79 | GPR183 (0.40) | ATXN2GPR183HCRTR1HCRTR2 | |
| SCHEMBL16963519 | 0.79 | GPR183 (0.40) | ATXN2GPR183HCRTR1HCRTR2 | |
| SCHEMBL16962449 | 0.78 | EPHX2 (0.46) | ATXN2 | |
| SCHEMBL21322944 | 0.75 | MEN1 (0.40) | ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |