Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATXN2 | Q99700 | 4/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | RBP4 | P02753 | 4/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16962750 | 1.00 | ATXN2 (0.39) | ATXN2ENPP2HSD11B1RBP4DGAT2 | |
| SCHEMBL16962449 | 0.89 | EPHX2 (0.46) | ATXN2ENPP2RBP4DGAT2MAPT | |
| SCHEMBL21313874 | 0.88 | ACHE (0.41) | ATXN2HCRTR1HCRTR2GPR183ACHE | |
| SCHEMBL16962635 | 0.86 | ENPP2 (0.44) | ATXN2ENPP2HSD11B1RBP4DGAT2 | |
| SCHEMBL16962636 | 0.86 | ENPP2 (0.44) | ATXN2ENPP2HSD11B1RBP4DGAT2 | |
| SCHEMBL16962634 | 0.86 | ENPP2 (0.44) | ATXN2ENPP2HSD11B1RBP4DGAT2 | |
| SCHEMBL21323193 | 0.84 | ATXN2 (0.40) | ATXN2ENPP2DGAT2CA2 | |
| SCHEMBL16963182 | 0.84 | ATXN2 (0.40) | ATXN2ENPP2DGAT2CA2 | |
| SCHEMBL21322927 | 0.81 | GPR183 (0.40) | ATXN2ENPP2HSD11B1RBP4HCRTR1 | |
| SCHEMBL16963519 | 0.81 | GPR183 (0.40) | ATXN2ENPP2HSD11B1RBP4HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |