Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963192 | 1.00 | GHSR (0.35) | GHSRHPGDNPC1MAPTRAB9A | |
| SCHEMBL21313985 | 0.89 | HTR2B (0.38) | GHSRHPGDNPC1MAPTRAB9A | |
| SCHEMBL16961534 | 0.89 | HTR2B (0.38) | GHSRHPGDNPC1MAPTRAB9A | |
| SCHEMBL21313868 | 0.89 | RAB9A (0.43) | HPGDNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL16963404 | 0.89 | RAB9A (0.43) | HPGDNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL21313927 | 0.87 | HTR2B (0.36) | GHSRHPGDNPC1MAPTRAB9A | |
| SCHEMBL16963202 | 0.87 | HTR2B (0.36) | GHSRHPGDNPC1MAPTRAB9A | |
| SCHEMBL16963193 | 0.86 | GHSR (0.39) | GHSRHPGDGPR183HTR2B | |
| SCHEMBL16963190 | 0.86 | GHSR (0.39) | GHSRHPGDGPR183HTR2B | |
| SCHEMBL16963356 | 0.85 | MKNK1 (0.38) | GHSRHPGDGPR183HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |