Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.35 |
| ▸ | BCR | P11274 | 3/20 | 0.35 |
| ▸ | GPR183 | P32249 | 2/20 | 0.34 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16961534 | 1.00 | HTR2B (0.38) | HTR2BGHSRNAMPTABL1BCR | |
| SCHEMBL16963192 | 0.89 | GHSR (0.35) | HTR2BGHSRGPR183HPGDNPC1 | |
| SCHEMBL21313929 | 0.89 | GHSR (0.35) | HTR2BGHSRGPR183HPGDNPC1 | |
| SCHEMBL21313868 | 0.89 | RAB9A (0.43) | GPR183HPGDNPC1MAPTRAB9A | |
| SCHEMBL16963404 | 0.89 | RAB9A (0.43) | GPR183HPGDNPC1MAPTRAB9A | |
| SCHEMBL21314079 | 0.88 | GPR183 (0.35) | GHSRNAMPTGPR183HPGDNPC1 | |
| SCHEMBL16961653 | 0.88 | GPR183 (0.35) | GHSRNAMPTGPR183HPGDNPC1 | |
| SCHEMBL16963356 | 0.86 | MKNK1 (0.38) | HTR2BGHSRNAMPTABL1BCR | |
| SCHEMBL21313888 | 0.86 | MKNK1 (0.38) | HTR2BGHSRNAMPTABL1BCR | |
| SCHEMBL16961532 | 0.86 | HTR2B (0.41) | HTR2BGHSRNAMPTABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |