Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.55 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.52 |
| ▸ | WNT1 | P04628 | 2/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.45 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10213929 | 0.78 | JAK2 (0.81) | JAK2DYRK1APDPK1TYK2JAK3 | |
| SCHEMBL21318857 | 0.75 | JAK2 (0.56) | JAK2DYRK1AWNT1TYK2JAK3 | |
| SCHEMBL17665913 | 0.74 | MAP4K4 (0.61) | MAP4K4 | |
| SCHEMBL10213963 | 0.74 | JAK2 (0.69) | JAK2DYRK1AWNT1JAK3DAPK3 | |
| SCHEMBL30588952 | 0.74 | JAK2 (0.69) | JAK2DYRK1AWNT1JAK3DAPK3 | |
| SCHEMBL21318652 | 0.73 | JAK2 (0.54) | JAK2DYRK1AWNT1TYK2JAK3 | |
| SCHEMBL12907171 | 0.72 | JAK2 (0.72) | JAK2DYRK1APDPK1TYK2JAK3 | |
| SCHEMBL31690865 | 0.72 | JAK2 (1.00) | JAK2DYRK1APDPK1TYK2JAK3 | |
| SCHEMBL24137841 | 0.72 | JAK2 (0.61) | JAK2DYRK1APDPK1TYK2JAK3 | |
| SCHEMBL24137493 | 0.72 | JAK2 (0.53) | JAK2DYRK1AWNT1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200787-B1 | INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME (US) | 2019-09-04 | — | — | EP | disclosed |