Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.54 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | MARK3 | P27448 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.45 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10213929 | 0.76 | JAK2 (0.81) | JAK2JAK3DYRK1APLK4DAPK3 | |
| SCHEMBL12907189 | 0.76 | JAK2 (0.66) | JAK2JAK3DYRK1APLK4DAPK3 | |
| SCHEMBL21318857 | 0.76 | JAK2 (0.56) | JAK2JAK3DYRK1APLK4DAPK3 | |
| SCHEMBL19398351 | 0.75 | MAP4K4 (0.58) | MAP4K4 | |
| SCHEMBL29968032 | 0.75 | JAK2 (0.65) | JAK2JAK3DYRK1APLK4DAPK3 | |
| SCHEMBL28871206 | 0.75 | JAK2 (0.65) | JAK2JAK3DYRK1APLK4DAPK3 | |
| SCHEMBL1142228 | 0.75 | JAK2 (0.64) | JAK2JAK3DYRK1APLK4DAPK3 | |
| Hydrochloric Acid SCHEMBL1141989 | 0.73 | JAK2 (0.62) | JAK2JAK3DYRK1APLK4DAPK3 | |
| SCHEMBL21318595 | 0.73 | JAK2 (0.56) | JAK2JAK3DYRK1APLK4DAPK3 | |
| SCHEMBL10213963 | 0.72 | JAK2 (0.69) | JAK2JAK3DYRK1ADAPK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200787-B1 | INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME (US) | 2019-09-04 | — | — | EP | disclosed |