Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 12/20 | 0.59 |
| ▸ | CLK3 | P49761 | 4/20 | 0.59 |
| ▸ | CLK2 | P49760 | 4/20 | 0.59 |
| ▸ | WNT1 | P04628 | 4/20 | 0.57 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 2/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30588952 | 1.00 | JAK2 (0.69) | JAK2DYRK1ACLK3CLK2WNT1 | |
| SCHEMBL6492377 | 0.88 | JAK2 (0.69) | JAK2DYRK1ACLK2CDK7CHEK1 | |
| SCHEMBL29942349 | 0.84 | MAP2K4 (0.64) | JAK2DYRK1ACLK3CLK2WNT1 | |
| SCHEMBL5514698 | 0.84 | MKNK1 (0.72) | JAK2DYRK1ACLK3CLK2WNT1 | |
| SCHEMBL17096938 | 0.83 | DYRK1A (0.67) | DYRK1ACLK3CLK2WNT1 | |
| SCHEMBL10213929 | 0.83 | JAK2 (0.81) | JAK2DYRK1ACLK2DAPK3PRKD3 | |
| SCHEMBL3359889 | 0.82 | JAK2 (1.00) | JAK2DYRK1ACLK2AURKADAPK3 | |
| SCHEMBL12907246 | 0.82 | JAK2 (1.00) | JAK2DYRK1ACLK2AURKADAPK3 | |
| SCHEMBL31690865 | 0.80 | JAK2 (1.00) | JAK2DYRK1ACLK2CDK7DAPK3 | |
| SCHEMBL31240306 | 0.79 | DYRK1A (0.71) | DYRK1ACLK3CLK2WNT1TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230272401-A1 | COMPOSITIONS FOR FLCN GENE MODULATION AND METHODS THEREOF | Genetic Intelligence, Inc | 2023-08-31 | — | — | US | disclosed |
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
| WO-2007117465-A2 | INDAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | JAK2 1822/4885DYRK1A 3722/4885CLK3 1887/4885 |
| US-20230272401-A1 | COMPOSITIONS FOR FLCN GENE MODULATION AND METHODS THEREOF | TARDBP, FUS, RBM17 | JAK2 4885/4885DYRK1A 4611/4885CLK3 3655/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | JAK2 1822/4885DYRK1A 3722/4885CLK3 1887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.