Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21318948 | 0.93 | SRC (0.39) | ADORA3ADORA1PPARGCTSBABL1 | |
| SCHEMBL21318947 | 0.90 | USP28 (0.39) | ADORA3ADORA1TLR7SMN1; SMN2LMNA | |
| SCHEMBL21318979 | 0.88 | ADORA3 (0.34) | ADORA3ADORA1PPARGCTSBABL1 | |
| SCHEMBL21318991 | 0.85 | — | — | |
| SCHEMBL23772953 | 0.85 | SMN1; SMN2 (0.37) | ADORA3ADORA1CTSBABL1SRC | |
| SCHEMBL19945665 | 0.85 | ABCB1 (0.38) | ADORA3ADORA1CTSBSMN1; SMN2MAPT | |
| SCHEMBL21319010 | 0.84 | PPARG (0.38) | ADORA3ADORA1PPARGSMN1; SMN2LMNA | |
| SCHEMBL21319065 | 0.76 | MEN1 (0.36) | ADORA3TLR7SMN1; SMN2LMNAMAPT | |
| SCHEMBL19945779 | 0.76 | MEN1 (0.36) | SMN1; SMN2LMNAMAPTTSHRL3MBTL1 | |
| SCHEMBL21319054 | 0.76 | ADORA3 (0.43) | ADORA3ADORA1CTSBABL1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294740-B1 | NOVEL SULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |