Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 2/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21322099 | 0.89 | MET (0.57) | METGPR119SLC2A1CHEK2HDAC1 | |
| SCHEMBL21264622 | 0.86 | MET (0.45) | METGPR119SLC2A1CHEK2HDAC1 | |
| SCHEMBL21322326 | 0.86 | MET (0.45) | METGPR119SLC2A1CHEK2HDAC1 | |
| SCHEMBL23714116 | 0.84 | MET (0.54) | METGPR119SLC2A1CHEK2HDAC1 | |
| SCHEMBL21264726 | 0.84 | GPR119 (0.51) | METGPR119SLC2A1CHEK2HDAC1 | |
| SCHEMBL21322331 | 0.83 | MET (0.50) | METGPR119NQO2 | |
| SCHEMBL21322264 | 0.83 | MET (0.47) | METGPR119SLC2A1CHEK2HDAC1 | |
| SCHEMBL22310752 | 0.83 | GPR119 (0.51) | METGPR119SLC2A1CHEK2HDAC1 | |
| SCHEMBL21264882 | 0.83 | MET (0.57) | METGPR119SLC2A1CHEK2HDAC1 | |
| SCHEMBL21322333 | 0.83 | MET (0.57) | METGPR119SLC2A1CHEK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3533787-B1 | PYRIDONE COMPOUND AS C-MET INHIBITOR | FUJIAN COSUNTER PHARMACEUTICAL CO LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3533787-A1 | PYRIDONE COMPOUND AS C-MET INHIBITOR | Fujian Cosunter Pharmaceutical Co., Ltd. (CN) | 2019-09-04 | — | — | EP | disclosed |