Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GPR183 | P32249 | 4/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963405 | 1.00 | RAB9A (0.42) | RAB9ANPC1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL16963403 | 1.00 | RAB9A (0.42) | RAB9ANPC1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL21322985 | 0.92 | RAB9A (0.47) | RAB9ANPC1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL21322987 | 0.92 | RAB9A (0.47) | RAB9ANPC1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL16963007 | 0.92 | RAB9A (0.47) | RAB9ANPC1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL16963005 | 0.92 | RAB9A (0.47) | RAB9ANPC1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL21322914 | 0.88 | ENPP2 (0.52) | HPGDGPR183ENPP2ATXN2 | |
| SCHEMBL16962439 | 0.88 | ENPP2 (0.52) | HPGDGPR183ENPP2ATXN2 | |
| SCHEMBL16962441 | 0.88 | ENPP2 (0.52) | HPGDGPR183ENPP2ATXN2 | |
| SCHEMBL16961652 | 0.88 | CHRNB2 (0.41) | GPR183CHRNB2CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |