Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5C | P41229 | 4/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.43 |
| ▸ | KDM4A | O75164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.40 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 2/20 | 0.39 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963777 | 1.00 | KDM5C (0.43) | KDM5CKDM4CKDM2AKDM4AKDM4E | |
| SCHEMBL18540872 | 0.94 | NAAA (0.45) | KDM5CKDM4CKDM2AKDM4AKDM4E | |
| SCHEMBL16962981 | 0.94 | NAAA (0.45) | KDM5CKDM4CKDM2AKDM4AKDM4E | |
| SCHEMBL21323059 | 0.88 | ENPP2 (0.52) | ENPP2ATXN2HPGD | |
| SCHEMBL16962855 | 0.88 | ENPP2 (0.52) | ENPP2ATXN2HPGD | |
| SCHEMBL21323107 | 0.88 | LSS (0.39) | ENPP2ATXN2 | |
| SCHEMBL21323349 | 0.88 | ENPP2 (0.43) | KDM4EENPP2ATXN2HPGD | |
| SCHEMBL16963841 | 0.88 | LSS (0.39) | ENPP2ATXN2 | |
| SCHEMBL16962369 | 0.88 | ENPP2 (0.43) | KDM4EENPP2ATXN2HPGD | |
| SCHEMBL21322941 | 0.87 | KDM5C (0.41) | KDM5CKDM4CKDM2AKDM4AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |