Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5C | P41229 | 4/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.41 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.40 |
| ▸ | BCR | P11274 | 3/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 2/20 | 0.38 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963412 | 1.00 | KDM5C (0.41) | KDM5CKDM4CKDM2AKDM4AKDM4E | |
| SCHEMBL16962981 | 0.89 | NAAA (0.45) | KDM5CKDM4CKDM2AKDM4AKDM4E | |
| SCHEMBL18540872 | 0.89 | NAAA (0.45) | KDM5CKDM4CKDM2AKDM4AKDM4E | |
| SCHEMBL20101595 | 0.89 | HTR2B (0.49) | HTR2BGHSRABL1BCRSLC6A7 | |
| SCHEMBL21323237 | 0.88 | GHSR (0.39) | KDM5CKDM4CKDM2AKDM4AKDM4E | |
| SCHEMBL16962954 | 0.88 | GHSR (0.39) | KDM5CKDM4CKDM2AKDM4AKDM4E | |
| SCHEMBL16963777 | 0.87 | KDM5C (0.43) | KDM5CKDM4CKDM2AKDM4AKDM4E | |
| SCHEMBL21322925 | 0.87 | KDM5C (0.43) | KDM5CKDM4CKDM2AKDM4AKDM4E | |
| SCHEMBL21323107 | 0.87 | LSS (0.39) | GHSR | |
| SCHEMBL16963841 | 0.87 | LSS (0.39) | GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |