Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATXN2 | Q99700 | 6/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963655 | 1.00 | ATXN2 (0.41) | ATXN2ENPP2DGAT2CHRNA7KCNH2 | |
| SCHEMBL16962369 | 0.88 | ENPP2 (0.43) | ATXN2ENPP2DGAT2TLR9TLR8 | |
| SCHEMBL21323349 | 0.88 | ENPP2 (0.43) | ATXN2ENPP2DGAT2TLR9TLR8 | |
| SCHEMBL16963657 | 0.85 | ENPP2 (0.34) | ATXN2ENPP2DGAT2CHRNA7KCNH2 | |
| SCHEMBL21323373 | 0.84 | ATXN2 (0.41) | ATXN2ENPP2DGAT2CHRNA7KCNH2 | |
| SCHEMBL16963800 | 0.84 | ATXN2 (0.41) | ATXN2ENPP2DGAT2CHRNA7KCNH2 | |
| SCHEMBL21323237 | 0.84 | GHSR (0.39) | ATXN2ENPP2DGAT2TLR9TLR8 | |
| SCHEMBL16962954 | 0.84 | GHSR (0.39) | ATXN2ENPP2DGAT2TLR9TLR8 | |
| SCHEMBL16963033 | 0.83 | ENPP2 (0.57) | ATXN2ENPP2DGAT2KCNH2GPBAR1 | |
| SCHEMBL16963383 | 0.83 | ENPP2 (0.57) | ATXN2ENPP2DGAT2KCNH2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |