Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 5/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.43 |
| ▸ | ATXN2 | Q99700 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963162 | 1.00 | ENPP2 (0.43) | ENPP2DGAT2ATXN2KDM4EKMT2A | |
| SCHEMBL16963033 | 0.88 | ENPP2 (0.57) | ENPP2DGAT2ATXN2KDM4EKMT2A | |
| SCHEMBL16963383 | 0.88 | ENPP2 (0.57) | ENPP2DGAT2ATXN2KDM4EKMT2A | |
| SCHEMBL16963684 | 0.88 | ENPP2 (0.57) | ENPP2DGAT2ATXN2KDM4EKMT2A | |
| SCHEMBL21323097 | 0.88 | ENPP2 (0.57) | ENPP2DGAT2ATXN2KDM4EKMT2A | |
| SCHEMBL16962522 | 0.86 | ENPP2 (0.59) | ENPP2DGAT2ATXN2 | |
| SCHEMBL21322925 | 0.85 | KDM5C (0.43) | ENPP2ATXN2KDM4E | |
| SCHEMBL16963777 | 0.85 | KDM5C (0.43) | ENPP2ATXN2KDM4E | |
| SCHEMBL16963165 | 0.85 | ENPP2 (0.38) | ENPP2DGAT2ATXN2KDM4EKMT2A | |
| SCHEMBL21323349 | 0.85 | ENPP2 (0.43) | ENPP2DGAT2ATXN2KDM4ETLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |