Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | DDO | Q99489 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26747131 | 0.81 | ALDH1A1 (0.49) | ALDH1A1HSD17B10MAPTHPGDUSP2 | |
| SCHEMBL28431982 | 0.78 | ALDH1A1 (0.62) | ALDH1A1HSD17B10MAPTHTTGAA | |
| SCHEMBL2722021 | 0.78 | ALDH1A1 (0.63) | ALDH1A1HSD17B10MAPTHPGDUSP2 | |
| SCHEMBL29897041 | 0.78 | ALDH1A1 (0.63) | ALDH1A1HSD17B10MAPTHPGDUSP2 | |
| SCHEMBL2399274 | 0.78 | ALDH1A1 (0.63) | ALDH1A1HSD17B10MAPTHPGDUSP2 | |
| SCHEMBL7678181 | 0.77 | GAA (0.63) | ALDH1A1HSD17B10MAPTHPGDGAA | |
| SCHEMBL9986859 | 0.77 | ALDH1A1 (0.58) | ALDH1A1HSD17B10MAPTHPGDUSP2 | |
| SCHEMBL10704376 | 0.76 | ALDH1A1 (0.61) | ALDH1A1HSD17B10MAPTHPGDUSP2 | |
| SCHEMBL2880010 | 0.76 | KDM4E (0.66) | ALDH1A1HSD17B10MAPTHPGDGAA | |
| SCHEMBL7679911 | 0.76 | GAA (0.53) | ALDH1A1MAPTGAAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11390609-B2 | Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof | BEIJING TIDE PHARMACEUTICAL CO., LTD. (CN) | 2022-07-19 | — | — | US | disclosed |
| US-11130749-B2 | — | — | 2021-09-28 | — | — | US | disclosed |
| US-20190276440-A1 | RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF | BEIJING TIDE PHARMACEUTICAL CO., LTD. (CN) | 2019-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11390609-B2 | Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof | ROCK1, ROCK2, RHOA | ALDH1A1 4501/4885HSD17B10 2976/4885MAPT 471/4885 |
| US-11130749-B2 | — | ROCK1, RHOA, ROCK2 | ALDH1A1 4171/4885HSD17B10 2384/4885MAPT 253/4885 |
| US-20190276440-A1 | RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF | ROCK1, ROCK2, RHOA | ALDH1A1 4501/4885HSD17B10 2976/4885MAPT 471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.