Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21331966 | 0.82 | DDB1 (0.47) | DDB1CRBNMAP2K1MMP1MMP13 | |
| SCHEMBL21331968 | 0.82 | DDB1 (0.47) | DDB1CRBNMAP2K1MMP1MMP13 | |
| SCHEMBL4768818 | 0.78 | DDB1 (0.44) | DDB1CRBNTSHRCYP19A1GAA | |
| SCHEMBL21332230 | 0.74 | FPR1 (0.44) | — | |
| SCHEMBL18117753 | 0.73 | TSHR (0.69) | MAP2K1TSHRALDH1A1PDE4APDE4B | |
| SCHEMBL1268717 | 0.73 | TSHR (0.69) | MAP2K1TSHRALDH1A1PDE4APDE4B | |
| SCHEMBL9537344 | 0.72 | DDB1 (0.56) | DDB1CRBNMMP1MMP13ALDH1A1 | |
| SCHEMBL27965543 | 0.70 | CRBN (0.71) | DDB1CRBNMMP1MMP13TSHR | |
| SCHEMBL19972309 | 0.69 | KDM1A (0.56) | DDB1CRBNMAP2K1TSHRPDE4A | |
| SCHEMBL19985875 | 0.69 | KDM1A (0.56) | DDB1CRBNMAP2K1TSHRPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019170904-A1 | PIPERIDINES OR PIPERIDONES SUBSTITUTED WITH UREA AND PHENYL | Grünenthal GmbH (DE) | 2019-09-12 | — | — | WO | disclosed |
| WO-2019170904-A1 | PIPERIDINES OR PIPERIDONES SUBSTITUTED WITH UREA AND PHENYL | Grünenthal GmbH (DE) | 2019-09-12 | — | — | WO | disclosed |