Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12463302 | 0.86 | HSD17B10 (0.57) | KDM4ELMNAHSD17B10CYP1A2SCN10A | |
| SCHEMBL11720785 | 0.81 | KDM4E (0.44) | KDM4ELMNAHSD17B10CYP1A2SCN10A | |
| SCHEMBL890080 | 0.80 | CYP1A2 (0.75) | KDM4ELMNAHSD17B10CYP1A2SCN10A | |
| SCHEMBL798790 | 0.80 | SCN10A (0.69) | KDM4ELMNAHSD17B10CYP1A2SCN10A | |
| SCHEMBL14267003 | 0.79 | ALPL (0.70) | KDM4ELMNAHSD17B10CYP1A2SCN10A | |
| SCHEMBL14197238 | 0.79 | KDM4E (0.57) | KDM4ELMNAHSD17B10CYP1A2SCN10A | |
| SCHEMBL11740622 | 0.79 | ALDH1A1 (0.61) | KDM4ELMNAHSD17B10CYP1A2SCN10A | |
| SCHEMBL521650 | 0.79 | KDM4E (0.58) | KDM4ELMNAHSD17B10CYP1A2SCN10A | |
| SCHEMBL2705606 | 0.77 | KDM4E (0.65) | KDM4ELMNAHSD17B10CYP1A2SCN10A | |
| SCHEMBL12938095 | 0.77 | KDM4E (0.69) | KDM4ELMNAHSD17B10CYP1A2SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10407421-B2 | Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections | MERCK SHARP & DOHME CORP (US) | 2019-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10407421-B2 | Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections | MGAM, BMX, XDH | KDM4E 1189/4885LMNA 1090/4885HSD17B10 1359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.