Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 18/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 17/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21337250 | 0.85 | SIGMAR1 (0.48) | SIGMAR1OPRM1 | |
| SCHEMBL21337586 | 0.78 | SIGMAR1 (0.62) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL18458660 | 0.78 | OPRM1 (1.00) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL21337397 | 0.73 | SIGMAR1 (0.50) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL18426780 | 0.73 | SIGMAR1 (0.87) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL22445667 | 0.72 | SIGMAR1 (0.62) | SIGMAR1OPRM1KCNH2ACHE | |
| SCHEMBL18458977 | 0.71 | SIGMAR1 (0.54) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL21337445 | 0.71 | SIGMAR1 (0.52) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL18425865 | 0.71 | SIGMAR1 (0.68) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL20599284 | 0.71 | OPRM1 (0.69) | SIGMAR1OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3328853-B1 | SUBSTITUTED AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS SA (ES) | 2019-09-11 | — | — | EP | disclosed |