Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | METAP1 | P53582 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11478271 | 0.85 | CBFB (0.47) | METAP2NPC1RAB9AMETAP1LMNA | |
| SCHEMBL13729712 | 0.81 | ERCC1 (0.56) | NPC1RAB9ALMNASMN1; SMN2HPGD | |
| SCHEMBL11881087 | 0.80 | PIN1 (0.64) | METAP2NPC1RAB9AMETAP1LMNA | |
| Oxalic Acid SCHEMBL28350889 | 0.78 | PIN1 (0.60) | METAP2NPC1RAB9AMETAP1LMNA | |
| SCHEMBL28350887 | 0.74 | PIN1 (0.49) | METAP2NPC1RAB9AMETAP1LMNA | |
| SCHEMBL3112137 | 0.74 | NPC1 (0.49) | NPC1RAB9ALMNASMN1; SMN2PKM | |
| SCHEMBL13726218 | 0.74 | KMT2A (0.47) | METAP2NPC1RAB9AMETAP1LMNA | |
| SCHEMBL10679715 | 0.73 | OPRK1 (0.54) | METAP2NPC1RAB9AMETAP1LMNA | |
| SCHEMBL10647635 | 0.73 | PIN1 (0.65) | METAP2NPC1RAB9AMETAP1LMNA | |
| SCHEMBL13982947 | 0.73 | KDM4E (0.50) | METAP2NPC1RAB9AMETAP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | claimed |
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |