Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.61 |
| ▸ | TRPA1 | O75762 | 8/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.53 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3560175 | 0.82 | AXL (0.73) | AXLTRPA1TRPM8TLR8MKNK1 | |
| SCHEMBL19522374 | 0.82 | TRPA1 (0.53) | AXLTRPA1TRPM8HPGDCHEK1 | |
| SCHEMBL20617830 | 0.77 | AXL (0.67) | AXLTRPA1TRPM8TLR8MKNK1 | |
| SCHEMBL20618760 | 0.76 | TRPA1 (0.50) | AXLTRPA1TRPM8CHEK1PKM | |
| SCHEMBL1541999 | 0.76 | AXL (0.65) | AXLTRPA1TRPM8TLR8MKNK1 | |
| SCHEMBL24358770 | 0.76 | AXL (0.65) | AXLTRPA1TRPM8TLR8MKNK1 | |
| SCHEMBL30153817 | 0.76 | AXL (0.65) | AXLTRPA1TRPM8TLR8MKNK1 | |
| SCHEMBL359039 | 0.76 | AXL (0.65) | AXLTRPA1TRPM8TLR8MKNK1 | |
| SCHEMBL1542113 | 0.76 | AXL (1.00) | AXLTRPA1TRPM8TLR8MKNK1 | |
| SCHEMBL9917349 | 0.75 | AXL (0.64) | AXLTRPA1TRPM8TLR8MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230030115-A1 | RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF | BEIJING TIDE PHARMACEUTICAL CO LTD (CN) | 2023-02-02 | — | — | US | disclosed |
| US-20190276440-A1 | RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF | BEIJING TIDE PHARMACEUTICAL CO., LTD. (CN) | 2019-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230030115-A1 | RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF | ROCK1, ROCK2, RHOA | AXL 2844/4885TRPA1 4790/4885TRPM8 4540/4885 |
| US-20190276440-A1 | RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF | ROCK1, ROCK2, RHOA | AXL 2844/4885TRPA1 4790/4885TRPM8 4540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.