Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.60 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA5A | P35218 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453018 | 0.84 | CA1 (0.67) | RAB9ANPC1ALDH1A1LMNAMEN1 | |
| SCHEMBL2028409 | 0.84 | CA1 (0.69) | RAB9ANPC1HDAC6LMNAMEN1 | |
| SCHEMBL259393 | 0.83 | NPC1 (0.67) | RAB9ANPC1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL31240480 | 0.81 | GSK3A (0.63) | RAB9AMAPTNPC1MEN1KMT2A | |
| SCHEMBL6436243 | 0.81 | CA1 (0.59) | RAB9AMAPTNPC1ALDH1A1MEN1 | |
| SCHEMBL6931979 | 0.79 | F2 (0.58) | RAB9AMAPTNPC1GRM4HDAC6 | |
| SCHEMBL10576461 | 0.78 | CA1 (0.67) | RAB9AMAPTNPC1HDAC6ALDH1A1 | |
| SCHEMBL11617075 | 0.78 | SMN1; SMN2 (0.62) | RAB9AMAPTNPC1GRM4HDAC6 | |
| SCHEMBL2530324 | 0.78 | GRM4 (1.00) | RAB9ANPC1GRM4HDAC6KDR | |
| SCHEMBL11531211 | 0.78 | KMT2A (0.76) | RAB9AMAPTNPC1ALDH1A1KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9463187-B2 | Methylphenidate derivatives and uses of them | AMPIO PHARMACEUTICALS, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-20120101129-A1 | Methylphenidate Derivatives and Uses of Them | AMPIO PHARMACEUTICALS, INC. | 2012-04-26 | — | — | US | disclosed |
| US-8076485-B2 | Methylphenidate derivatives and uses of them | INSTITUTE FOR MOLECULAR MEDICINE, INC. (US) | 2011-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101129-A1 | Methylphenidate Derivatives and Uses of Them | SLC6A3, COMT, UGT1A1 | RAB9A 1329/4885MAPT 1011/4885NPC1 390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.