Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.67 |
| ▸ | CA2 | P00918 | 1/20 | 0.67 |
| ▸ | CA5A | P35218 | 1/20 | 0.67 |
| ▸ | CA7 | P43166 | 1/20 | 0.67 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 7/20 | 0.64 |
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | CNR1 | P21554 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | NPY2R | P49146 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2028409 | 0.87 | CA1 (0.69) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL10576461 | 0.85 | CA1 (0.67) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL6491441 | 0.85 | CA1 (0.71) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL18546011 | 0.84 | CA1 (0.66) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL2134679 | 0.84 | RAB9A (0.67) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL29765433 | 0.84 | CA1 (0.65) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL6340653 | 0.82 | CA1 (0.63) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL16248330 | 0.81 | HTR1A (0.63) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL6436243 | 0.81 | CA1 (0.59) | CA1CA2CA5ACA7CA5B | |
| SCHEMBL6490174 | 0.80 | GCGR (0.54) | CA1CA2CA5ACA7CA5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896394-B1 | SUBSTITUTED ENAMINONES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | UNIV CALIFORNIA (US) | 2013-05-29 | — | — | EP | disclosed |
| US-7820663-B2 | Substituted enaminones, their derivatives and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-10-26 | — | — | US | disclosed |
| EP-1896394-A1 | SUBSTITUTED ENAMINONES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | The Regents of the University of California (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20060293329-A1 | Substituted enaminones, their derivatives and uses thereof | OXFORD FINANCE CORPORATION | 2006-12-28 | — | — | US | disclosed |
| WO-2006138510-A1 | SUBSTITUTED ENAMINONES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293329-A1 | Substituted enaminones, their derivatives and uses thereof | CHRNA7, CHRNA5, CHRNA1 | CA1 2918/4885CA2 3611/4885CA5A 1754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.