Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 3/20 | 0.52 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21347414 | 0.94 | MAPT (0.60) | MAPTL3MBTL1PDE4BPDE4DTP53 | |
| SCHEMBL21346964 | 0.86 | TP53 (0.56) | MAPTL3MBTL1PDE4BPDE4DTP53 | |
| SCHEMBL22971847 | 0.84 | MAPT (0.65) | MAPTL3MBTL1PDE4BPDE4DTP53 | |
| SCHEMBL22971976 | 0.81 | PDE4B (0.61) | MAPTL3MBTL1PDE4BPDE4DTP53 | |
| SCHEMBL21346818 | 0.79 | FLT3 (0.70) | MAPTL3MBTL1PDE4BPDE4DTP53 | |
| SCHEMBL2182372 | 0.76 | TP53 (0.80) | MAPTL3MBTL1PDE4BPDE4DTP53 | |
| SCHEMBL8289821 | 0.72 | MAPT (0.76) | MAPTL3MBTL1PDE4BPDE4DTP53 | |
| SCHEMBL3922433 | 0.71 | MEN1 (0.82) | MAPTL3MBTL1PDE4BPDE4DTP53 | |
| SCHEMBL21347432 | 0.71 | RAB9A (0.78) | MAPTL3MBTL1PDE4BPDE4DTP53 | |
| SCHEMBL5455162 | 0.69 | MAPT (0.72) | MAPTL3MBTL1PDE4BPDE4DTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019173437-A1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-09-12 | — | — | WO | disclosed |