Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | AIP | O00170 | 1/20 | 0.50 |
| ▸ | SGTA | O43765 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21347414 | 0.85 | MAPT (0.60) | PDE4BPDE4DKDM4EALDH1A1HPGD | |
| SCHEMBL22971847 | 0.82 | MAPT (0.65) | PDE4BPDE4DKDM4EALDH1A1HPGD | |
| SCHEMBL21347779 | 0.81 | MAPT (0.54) | PDE4BPDE4DKDM4EALDH1A1RAB9A | |
| SCHEMBL21346964 | 0.77 | TP53 (0.56) | PDE4BPDE4DKDM4EALDH1A1HPGD | |
| SCHEMBL21347434 | 0.76 | ALDH1A1 (0.62) | PDE4BPDE4DKDM4EALDH1A1HPGD | |
| SCHEMBL8290603 | 0.75 | ALDH1A1 (0.72) | PDE4BPDE4DKDM4EALDH1A1HPGD | |
| SCHEMBL5454136 | 0.71 | REV1 (0.81) | PDE4BPDE4DKDM4EALDH1A1HPGD | |
| SCHEMBL21346818 | 0.69 | FLT3 (0.70) | PDE4BPDE4DKDM4EALDH1A1RAB9A | |
| SCHEMBL21333819 | 0.69 | ALDH1A1 (0.66) | PDE4BPDE4DKDM4EALDH1A1HPGD | |
| SCHEMBL1066142 | 0.68 | FLT3 (0.68) | PDE4BPDE4DKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210040074-A1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040074-A1 | POSITIVE ALLOSTERIC MODULATORS OF DOPAMINE 1 RECEPTOR AND METHOD OF USE THEREOF | CHRM1, MTNR1A, CHRNA3 | PDE4B 485/4885PDE4D 247/4885KDM4E 4085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.