SCHEMBL21354583

SCHEMBL21354583

CC(C)(C)CC(=O)Nc1nc2ccc(C(C)(C)O)c(OC(F)(F)F)c2n1C1CCC1

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.35
IDH1 O75874 15/20 0.35
CSNK1D P48730 1/20 0.34
MAP3K7 O43318 1/20 0.33
IRAK4 Q9NWZ3 1/20 0.33
KCNQ3 O43525 1/20 0.33
KCNQ2 O43526 1/20 0.33
LIPE Q05469 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18779193 0.87 EGFR (0.35) EGFRCSNK1D
SCHEMBL30315379 0.86 ALK (0.36) EGFRIDH1CSNK1DMAP3K7IRAK4
SCHEMBL21354691 0.86 ALK (0.36) EGFRIDH1CSNK1DMAP3K7IRAK4
SCHEMBL21354564 0.84 IDH1 (0.33) EGFRIDH1CSNK1DMAP3K7IRAK4
SCHEMBL17582839 0.82 EGFR (0.40) EGFR
SCHEMBL21354685 0.82 EGFR (0.42) EGFRIDH1MAP3K7IRAK4KCNQ3
SCHEMBL18779199 0.80 EGFR (0.35) EGFR
SCHEMBL21390775 0.80 JAK1 (0.38) IDH1
SCHEMBL18779232 0.79 EGFR (0.36) EGFRCSNK1DKCNQ3KCNQ2
SCHEMBL21354602 0.78 ACACB (0.41) EGFRKCNQ3KCNQ2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062389-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE BOZIK MICHAEL E (US) 2026-03-05 US disclosed
US-12286408-B2 KV7 channel activators compositions and methods of use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-04-29 US disclosed
US-20240002349-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE BIOHAVEN THERAPEUTICS LTD (US) 2024-01-04 US disclosed
US-11724990-B2 Kv7 channel activators compositions and methods of use BIOHAVEN THERAPEUTICS LTD. (VG) 2023-08-15 US disclosed
US-11724990-B2 Kv7 channel activators compositions and methods of use BIOHAVEN THERAPEUTICS LTD. (VG) 2023-08-15 US disclosed
US-11724990-B2 Kv7 channel activators compositions and methods of use BIOHAVEN THERAPEUTICS LTD. (VG) 2023-08-15 US disclosed
US-20230000831-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE CHANNEL BIOSCIENCES, LLC 2023-01-05 US disclosed
US-20230000831-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE CHANNEL BIOSCIENCES, LLC 2023-01-05 US disclosed
US-11261162-B2 KV7 channel activators compositions and methods of use KNOPP BIOSCIENCES, LLC (US) 2022-03-01 US disclosed
US-20210130299-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-05-06 US disclosed
US-20210130299-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-05-06 US disclosed
US-10851067-B2 Kv7 channel activators compositions and methods of use KNOPP BIOSCIENCES LLC (US) 2020-12-01 US disclosed
US-10851067-B2 Kv7 channel activators compositions and methods of use KNOPP BIOSCIENCES LLC (US) 2020-12-01 US disclosed
US-20190284142-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE CHANNEL BIOSCIENCES, LLC 2019-09-19 US disclosed
US-20190284142-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE CHANNEL BIOSCIENCES, LLC 2019-09-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11261162-B2 KV7 channel activators compositions and methods of use KCNA7, KCNK17, KCNAB1 EGFR 4338/4885IDH1 2551/4885CSNK1D 646/4885
US-20190284142-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNK17, KCNAB1 EGFR 4338/4885IDH1 2551/4885CSNK1D 646/4885
US-11724990-B2 Kv7 channel activators compositions and methods of use KCNA7, KCNK17, KCNAB1 EGFR 4338/4885IDH1 2551/4885CSNK1D 646/4885
US-20230000831-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNK17, KCNAB1 EGFR 4338/4885IDH1 2551/4885CSNK1D 646/4885
US-10851067-B2 Kv7 channel activators compositions and methods of use KCNA7, KCNK17, KCNAB1 EGFR 4338/4885IDH1 2551/4885CSNK1D 646/4885
US-20260062389-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNH3, KCNA3 EGFR 2207/4885IDH1 2268/4885CSNK1D 329/4885
US-20210130299-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNK17, KCNAB1 EGFR 4338/4885IDH1 2551/4885CSNK1D 646/4885
US-12286408-B2 KV7 channel activators compositions and methods of use KCNA7, KCNK17, KCNAB1 EGFR 4338/4885IDH1 2551/4885CSNK1D 646/4885
US-20240002349-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNK17, KCNAB1 EGFR 4338/4885IDH1 2551/4885CSNK1D 646/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.