Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 7/20 | 0.38 |
| ▸ | JAK2 | O60674 | 5/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 3/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21354583 | 0.80 | EGFR (0.35) | IDH1 | |
| SCHEMBL21390761 | 0.66 | AR (0.43) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL21390872 | 0.66 | HCAR1 (0.36) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL17033108 | 0.66 | HCAR1 (0.48) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL18779199 | 0.64 | EGFR (0.35) | CYP2D6 | |
| SCHEMBL18779193 | 0.64 | EGFR (0.35) | CYP2D6 | |
| SCHEMBL21390823 | 0.64 | GAA (0.47) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL21391122 | 0.64 | CDK9 (0.51) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL21390686 | 0.64 | HCAR1 (0.40) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL17586640 | 0.63 | CYP11B2 (0.58) | HCAR1ADRB1ADRA2ACYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |