Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23859720 | 0.83 | LMNA (0.49) | SMN1; SMN2LMNAPOLBGBA2HRH2 | |
| SCHEMBL31532476 | 0.82 | LMNA (0.41) | SMN1; SMN2LMNAPOLBGBA2HRH2 | |
| SCHEMBL4768470 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAPOLBGBA2HRH2 | |
| SCHEMBL31365786 | 0.82 | LMNA (0.43) | SMN1; SMN2LMNAPOLBGBA2HRH2 | |
| SCHEMBL3313643 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL31131213 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAPOLBGBA2GPR119 | |
| SCHEMBL2360585 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAPOLBGBA2GPR119 | |
| SCHEMBL21401562 | 0.77 | L3MBTL1 (0.39) | SMN1; SMN2POLBALDH1A1ATML3MBTL1 | |
| SCHEMBL21384531 | 0.77 | L3MBTL1 (0.39) | SMN1; SMN2POLBALDH1A1ATML3MBTL1 | |
| SCHEMBL18639389 | 0.77 | LMNA (0.46) | SMN1; SMN2LMNAPOLBGBA2HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4326714-A1 | HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2024-02-28 | — | — | EP | disclosed |
| WO-2022223750-A1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2022-10-27 | — | — | WO | disclosed |
| EP-3765020-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | Escalier Biosciences B.V. (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019177997-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. (US) | 2019-09-19 | — | — | WO | disclosed |