⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21358501 | 0.75 | GPR119 (0.35) | — | |
| SCHEMBL18547240 | 0.73 | — | — | |
| SCHEMBL16281289 | 0.73 | HSD11B1 (0.32) | — | |
| SCHEMBL633200 | 0.71 | ACHE (0.43) | — | |
| SCHEMBL21358497 | 0.71 | SMYD3 (0.31) | — | |
| SCHEMBL29460270 | 0.71 | ACHE (0.43) | — | |
| Trifluoroacetic Acid SCHEMBL29494753 | 0.71 | KDM4E (0.33) | — | |
| Hydrochloric Acid SCHEMBL19996108 | 0.70 | ACHE (0.41) | — | |
| SCHEMBL19640910 | 0.69 | AKR1C3 (0.52) | — | |
| SCHEMBL19640886 | 0.69 | AKR1C3 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106329-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B V (US) | 2022-04-07 | — | — | US | disclosed |
| US-11230555-B2 | Bicyclic RORγ modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-01-25 | — | — | US | disclosed |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| EP-3765009-A1 | BICYCLIC ROR-GAMMA MODULATORS | Escalier Biosciences, BV (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019177996-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. (US) | 2019-09-19 | — | — | WO | disclosed |