Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21358441 | 0.86 | KLK7 (0.36) | MITFMAPTHTTPDK1PDK2 | |
| SCHEMBL31367114 | 0.83 | TP53 (0.40) | HTTNPSR1PREPSMN1; SMN2ALDH1A1 | |
| SCHEMBL21367041 | 0.83 | TP53 (0.40) | HTTNPSR1PREPSMN1; SMN2ALDH1A1 | |
| SCHEMBL22118726 | 0.83 | TP53 (0.40) | HTTNPSR1PREPSMN1; SMN2ALDH1A1 | |
| SCHEMBL31367163 | 0.81 | HTT (0.37) | MITFMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL31367151 | 0.79 | HTR2C (0.43) | MITFMAPTHTTNPSR1PDK1 | |
| SCHEMBL21358090 | 0.79 | PDE4B (0.46) | MITFMAPTHTTNPSR1SMN1; SMN2 | |
| SCHEMBL21358147 | 0.78 | SMN1; SMN2 (0.39) | PREPSMN1; SMN2NPC1RAB9A | |
| SCHEMBL21358094 | 0.78 | PDK1 (0.36) | MITFMAPTHTTNPSR1PSEN1 | |
| SCHEMBL31367126 | 0.78 | CPB1 (0.38) | MITFMAPTHTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765006-A1 | ARGINASE INHIBITORS AND METHODS OF USE | Merck Sharp&Dohme Corp. (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019177873-A1 | ARGINASE INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2019-09-19 | — | — | WO | disclosed |