Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.39 |
| ▸ | CTSG | P08311 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21367041 | 0.86 | TP53 (0.40) | SMN1; SMN2NPC1RAB9AF2ELANE | |
| SCHEMBL22118726 | 0.86 | TP53 (0.40) | SMN1; SMN2NPC1RAB9AF2ELANE | |
| SCHEMBL31367114 | 0.86 | TP53 (0.40) | SMN1; SMN2NPC1RAB9AF2ELANE | |
| SCHEMBL21358644 | 0.78 | MITF (0.36) | SMN1; SMN2NPC1RAB9APREP | |
| SCHEMBL16329051 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AELANEPREP | |
| SCHEMBL31367163 | 0.77 | HTT (0.37) | SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL21358090 | 0.76 | PDE4B (0.46) | SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL31367121 | 0.75 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1RAB9APREPCYP2C19 | |
| SCHEMBL21358094 | 0.75 | PDK1 (0.36) | SMN1; SMN2NPC1RAB9APREP | |
| SCHEMBL31367151 | 0.74 | HTR2C (0.43) | SMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765006-A1 | ARGINASE INHIBITORS AND METHODS OF USE | Merck Sharp&Dohme Corp. (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019177873-A1 | ARGINASE INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2019-09-19 | — | — | WO | disclosed |