Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 8/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21358576 | 0.88 | SLC40A1 (0.44) | SLC40A1PARP1KDM4EGMNNLMNA | |
| SCHEMBL21359924 | 0.79 | MEN1 (0.41) | CYP2D6NFKB1SMN1; SMN2HIF1A | |
| SCHEMBL19056875 | 0.77 | SLC40A1 (0.45) | SLC40A1KDM4EGMNNLMNATP53 | |
| SCHEMBL21905591 | 0.75 | IDH1 (0.40) | KDM4E | |
| SCHEMBL19056869 | 0.74 | SLC40A1 (0.43) | SLC40A1KDM4EGMNNLMNATP53 | |
| SCHEMBL19056880 | 0.70 | SLC40A1 (0.39) | SLC40A1KDM4EGMNNLMNATP53 | |
| SCHEMBL16823472 | 0.70 | IDH1 (0.37) | KDM4EMAPTALDH1A1 | |
| SCHEMBL13154645 | 0.70 | LMNA (0.52) | SLC40A1KDM4EGMNNLMNATP53 | |
| SCHEMBL9138052 | 0.67 | SLC40A1 (0.49) | SLC40A1KDM4EGMNNLMNATP53 | |
| SCHEMBL3375947 | 0.67 | PARP1 (0.48) | SLC40A1PARP1KDM4EGMNNLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019177937-A1 | SUBSTITUTED 2-PYRIDONE TRICYCLIC COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2019-09-19 | — | — | WO | disclosed |