Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 11/20 | 0.37 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | MMP2 | P08253 | 5/20 | 0.35 |
| ▸ | MMP14 | P50281 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CPS1 | P31327 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23102230 | 0.90 | ROCK2 (0.39) | ROCK2CYP1A2PRKG1ADAMTS5MMP13 | |
| SCHEMBL21361621 | 0.82 | CPS1 (0.36) | ROCK2CYP1A2PRKG1ADAMTS5MMP13 | |
| SCHEMBL21361434 | 0.75 | ROCK2 (0.35) | ROCK2CYP1A2PRKG1ADAMTS5LMNA | |
| SCHEMBL13899013 | 0.72 | KDM4E (0.44) | CYP1A2MAPTKDM4ELMNAHTT | |
| SCHEMBL21358949 | 0.71 | ADRB1 (0.49) | CYP1A2 | |
| SCHEMBL21358947 | 0.71 | ADRB1 (0.49) | CYP1A2 | |
| SCHEMBL21359189 | 0.71 | ADRB1 (0.49) | CYP1A2 | |
| SCHEMBL17897270 | 0.68 | ADAMTS5 (0.43) | CYP1A2ADAMTS5MMP2MAPTKDM4E | |
| SCHEMBL19003576 | 0.68 | ADAMTS5 (0.43) | CYP1A2ADAMTS5MMP2MAPTKDM4E | |
| SCHEMBL17897284 | 0.68 | ADAMTS5 (0.43) | CYP1A2ADAMTS5MMP2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019178510-A1 | TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-09-19 | — | — | WO | disclosed |