Sugi Predict

Sugi Predict / Compounds / SCHEMBL21361558

SCHEMBL21361558

SCHEMBL21361558

C[C@@H]1CCN(S(=O)(=O)N2CCc3cc(Cl)ccc3C2)CCCN(CC2CCCCC2)CCCN1S(=O)(=O)c1ccc(N(C)C)cc1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ PSEN1 P49768 3/20 0.42
▸ PSEN2 P49810 3/20 0.42
▸ APH1B Q8WW43 3/20 0.42
▸ NCSTN Q92542 3/20 0.42
▸ APH1A Q96BI3 3/20 0.42
▸ PSENEN Q9NZ42 3/20 0.42
▸ PDE4B Q07343 1/20 0.36
▸ AKR1C3 P42330 6/20 0.35
▸ ALOX5 P09917 1/20 0.35
▸ AKR1C1 Q04828 1/20 0.35
▸ HRH3 Q9Y5N1 3/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ OPRK1 P41145 1/20 0.34
▸ DRD2 P14416 1/20 0.33
▸ PTGDR2 Q9Y5Y4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21361557 1.00 PSEN1 (0.42) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL21361555 0.94 PSEN1 (0.38) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL21361459 0.94 PSEN1 (0.38) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL21361453 0.90 PDE4B (0.35) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL21361457 0.90 PDE4B (0.35) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL23102262 0.88 PDE4B (0.35) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL21361533 0.88 OPRK1 (0.39) PDE4BAKR1C3ALOX5AKR1C1HRH3
SCHEMBL21361472 0.87 OPRK1 (0.40) PDE4BAKR1C3ALOX5AKR1C1OPRK1
SCHEMBL21361403 0.87 CD4 (0.45) PDE4BAKR1C3ALOX5AKR1C1HRH3
SCHEMBL21361454 0.87 OPRK1 (0.37) PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3765447-B1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS KEZAR LIFE SCIENCES (US) 2023-07-12 — — EP disclosed
EP-3765447-B1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS KEZAR LIFE SCIENCES (US) 2023-07-12 — — EP disclosed
US-11578055-B2 Triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors KEZAR LIFE SCIENCES (US) 2023-02-14 — — US disclosed
US-20220402891-A1 TRIAZACYCLODODECANSULFONAMIDE (TCD)-BASED PROTEIN SECRETION INHIBITORS ENODIA THERAPEUTICS SAS (FR) 2022-12-22 — — US disclosed
US-20210078974-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS ENODIA THERAPEUTICS SAS (FR) 2021-03-18 — — US disclosed
WO-2019178510-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS KEZAR LIFE SCIENCES (US) 2019-09-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11578055-B2 Triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors SEC61B, SEC61A1, SEC61G PSEN1 2622/4885PSEN2 3223/4885APH1B 2021/4885
US-20220402891-A1 TRIAZACYCLODODECANSULFONAMIDE (TCD)-BASED PROTEIN SECRETION INHIBITORS SEC61B, SEC61A1, SEC61G PSEN1 2623/4885PSEN2 3291/4885APH1B 2052/4885
US-20210078974-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS SEC61B, SEC61A1, SEC61G PSEN1 2566/4885PSEN2 3276/4885APH1B 2200/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.