Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.58 |
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22862244 | 0.88 | NPC1 (0.61) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL3413937 | 0.78 | NPC1 (0.63) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL14120645 | 0.78 | NPC1 (0.50) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL22862227 | 0.78 | NPC1 (0.51) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL22908292 | 0.77 | NPC1 (0.62) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL21361937 | 0.76 | HPGD (0.70) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL21361939 | 0.76 | NPC1 (0.65) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL15464134 | 0.74 | MME (0.81) | — | |
| SCHEMBL9936662 | 0.74 | MME (0.81) | — | |
| SCHEMBL28552695 | 0.74 | MEN1 (0.43) | NPC1RAB9AL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11091450-B2 | Crystal of a caspase inhibitor | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2021-08-17 | — | — | US | disclosed |
| EP-3766873-A1 | METHOD FOR PREPARING CASPASE INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-01-20 | — | — | EP | disclosed |
| US-20210002235-A1 | A CRYSTAL OF A CASPASE INHIBITOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2021-01-07 | — | — | US | disclosed |
| WO-2019174589-A1 | METHOD FOR PREPARING CASPASE INHIBITOR | 正大天晴药业集团股份有限公司 | 2019-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002235-A1 | A CRYSTAL OF A CASPASE INHIBITOR | CASP1, CASP7, CASP14 | NPC1 2675/4885RAB9A 4344/4885L3MBTL1 3289/4885 |
| US-11091450-B2 | Crystal of a caspase inhibitor | CASP1, CASP14, CASP7 | NPC1 2920/4885RAB9A 4477/4885L3MBTL1 3318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.