Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.30 |
| ▸ | KDM4A | O75164 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21362444 | 0.91 | PRMT5 (0.43) | PRMT5WDR77KDM4ELMNAKCNA5 | |
| SCHEMBL20157334 | 0.76 | PRMT5 (0.48) | PRMT5WDR77KDM4ELMNAKCNA5 | |
| SCHEMBL20157341 | 0.71 | KDM4E (0.40) | PRMT5WDR77KDM4ELMNAKCNA5 | |
| SCHEMBL20157285 | 0.71 | HDAC10 (0.40) | PRMT5WDR77KDM4ELMNAKCNA5 | |
| SCHEMBL3490524 | 0.66 | PRMT5 (0.57) | PRMT5WDR77AAK1CA1CA2 | |
| SCHEMBL21362755 | 0.66 | KCNA5 (0.37) | PRMT5WDR77KDM4ELMNAKCNA5 | |
| SCHEMBL13837691 | 0.64 | NAMPT (0.47) | KDM4ELMNAL3MBTL1CA1CA2 | |
| SCHEMBL21550130 | 0.64 | KDM4E (0.42) | PRMT5WDR77KDM4ELMNAKCNA5 | |
| SCHEMBL1290158 | 0.64 | PRMT5 (0.57) | PRMT5WDR77KCNA5AAK1CA1 | |
| SCHEMBL21550012 | 0.62 | AAK1 (0.38) | PRMT5WDR77AAK1CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |