Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157788 | 0.87 | BRD4 (0.43) | BRD4KDM4EPTPRCKMT2AMAPT | |
| SCHEMBL21362517 | 0.83 | BRD4 (0.40) | BRD4KDM4EPTPRCKMT2AP2RX3 | |
| SCHEMBL21362150 | 0.83 | BRD4 (0.40) | BRD4KDM4EPTPRCKMT2AP2RX3 | |
| SCHEMBL21362559 | 0.78 | BRD4 (0.52) | BRD4KDM4EKMT2AMAPTALDH1A1 | |
| SCHEMBL21362563 | 0.77 | BRD4 (0.53) | BRD4KDM4EKMT2AMAPTALDH1A1 | |
| SCHEMBL20157810 | 0.76 | BRD4 (0.46) | BRD4KDM4EKMT2AALDH1A1LMNA | |
| SCHEMBL21352026 | 0.76 | BRD4 (0.48) | BRD4KDM4EKMT2AMAPTALDH1A1 | |
| SCHEMBL21351879 | 0.76 | BRD4 (0.50) | BRD4KDM4EKMT2AMAPTALDH1A1 | |
| SCHEMBL21362103 | 0.74 | BRD4 (0.46) | BRD4KDM4EKMT2AMAPTALDH1A1 | |
| SCHEMBL27536809 | 0.74 | GABRP (0.40) | MAPTLMNAHTTGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |