Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ERN1 | O75460 | 4/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776519 | 0.80 | ALDH1A1 (0.47) | PRKDCLMNAERN1TRIM24TRIM33 | |
| SCHEMBL2279052 | 0.78 | TDP1 (0.44) | PRKDCLMNATDP1ERN1ALDH1A1 | |
| SCHEMBL12375092 | 0.77 | TERT (0.43) | PRKDCLMNATDP1ERN1ALDH1A1 | |
| SCHEMBL20607737 | 0.76 | PRKDC (0.42) | PRKDCLMNAERN1TRIM24TRIM33 | |
| SCHEMBL16706976 | 0.76 | LMNA (0.46) | PRKDCLMNATDP1ERN1ALDH1A1 | |
| SCHEMBL3253021 | 0.74 | TERT (0.45) | LMNATDP1ERN1ALDH1A1MAPT | |
| SCHEMBL20535669 | 0.73 | LMNA (0.43) | PRKDCLMNATDP1ERN1ALDH1A1 | |
| SCHEMBL380731 | 0.72 | TDP1 (0.61) | PRKDCLMNATDP1ERN1TRIM24 | |
| SCHEMBL20535344 | 0.72 | LMNA (0.53) | LMNATDP1ALDH1A1MAPTHPGD | |
| SCHEMBL6094668 | 0.72 | ERN1 (0.57) | LMNATDP1ERN1TRIM24TRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |