Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 19/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 18/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 18/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 18/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 18/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 18/20 | 0.51 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.51 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.51 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21362574 | 0.94 | GABRA5 (0.54) | GABRA5GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL21362458 | 0.92 | GABRA1 (0.51) | GABRA5GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL21362652 | 0.91 | GABRA5 (0.53) | GABRA5GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL21362598 | 0.91 | GABRA5 (0.53) | GABRA5GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL21362481 | 0.90 | GABRA5 (0.52) | GABRA5GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL26016232 | 0.90 | GABRA1 (0.53) | GABRA5GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL21362682 | 0.90 | GABRA5 (0.53) | GABRA5GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL21362476 | 0.90 | GABRA1 (0.55) | GABRA5GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL18973212 | 0.89 | GABRA5 (0.53) | GABRA5GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL21362600 | 0.88 | GABRA1 (0.50) | GABRA5GABRA1GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3766882-B1 | PHTHALAZINE ISOXAZOLE ALKOXY DERIVATIVES, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI SIMR BIOTECHNOLOGY CO LTD (CN) | 2023-08-23 | — | — | EP | disclosed |
| CN-110256440-B | Phthalazine isoxazole alkoxy derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2023-05-23 | — | — | CN | disclosed |
| EP-3766882-A1 | PHTHALAZINE ISOXAZOLE ALKOXY DERIVATIVES, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Simr Biotechnology Co., Ltd. (CN) | 2021-01-20 | — | — | EP | disclosed |
| US-20210009598-A1 | PHTHALAZINE ISOXAZOLE ALKOXY DERIVATIVES, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai SIMRD Biotechnology Co., Ltd (CN) | 2021-01-14 | — | — | US | disclosed |
| WO-2019174577-A1 | PHTHALAZINE ISOXAZOLE ALKOXY DERIVATIVES, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 上海赛默罗生物科技有限公司 | 2019-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009598-A1 | PHTHALAZINE ISOXAZOLE ALKOXY DERIVATIVES, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | GABRA5, CYP3A5, GABRA4 | GABRA5 1/4885GABRA1 6/4885GABRG2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.